In 1997, I did a research project at the National CJD Research and Surveillance Unit at Edinburgh’s Western General Hospital, supervised by Robert Will and James Ironside, who co-authored the 1996 paper in the Lancet that proposed the existence ofvCJD in the UK. The only reliable way to diagnose the disease was by post-mortem examination of the brain, which would reveal the tiny holes in the brain tissue caused by massive cell death – giving it a sponge-like appearance – and allow us to test for the presence of abnormal proteins.